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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP2B All Species: 22.73
Human Site: S1435 Identified Species: 35.71
UniProt: Q02880 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q02880 NP_001059.2 1626 183267 S1435 S K A T P E K S L H D K K S Q
Chimpanzee Pan troglodytes XP_516332 1634 184611 S1443 S K A T P E K S L H D K K S Q
Rhesus Macaque Macaca mulatta XP_001092092 1620 182490 S1429 S K A T P E K S L H D K K S Q
Dog Lupus familis XP_534241 2041 231068 S1852 S K A T P E K S S H D K K S Q
Cat Felis silvestris
Mouse Mus musculus Q64511 1612 181890 S1422 S K A T P E K S S N D K K S Q
Rat Rattus norvegicus P41516 1526 173202 F1345 K D E D E D F F P L D D T P P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507216 1923 216719 S1735 S K P T P E K S S H D K K N Q
Chicken Gallus gallus O42131 1627 183228 M1441 S K P S P E K M S Q E K K N Q
Frog Xenopus laevis NP_001082502 1579 178601 E1397 A E K A K K T E S P E N A P P
Zebra Danio Brachydanio rerio NP_001038656 1618 182448 T1427 D D I F P P K T T F T L P T S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P15348 1447 164377 P1266 K P K E P K E P K V K K E P K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23670 1520 172316 N1339 K E K S D G F N S D M S E E S
Sea Urchin Strong. purpuratus XP_783546 1448 163750 G1267 N L I K K A T G D G K R G R K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P30182 1473 164089 A1292 K K K A P A A A K E V E E D E
Baker's Yeast Sacchar. cerevisiae P06786 1428 164196 K1247 K A P T K I K K E K T P S V S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 98.5 78.1 N.A. 95.6 66.2 N.A. 79.3 89.2 66.6 73.6 N.A. 50.3 N.A. 49.5 57.3
Protein Similarity: 100 98.5 99.1 78.8 N.A. 97.2 78.1 N.A. 81.8 93.8 78.7 83.8 N.A. 64.3 N.A. 65.8 69.9
P-Site Identity: 100 100 100 93.3 N.A. 86.6 6.6 N.A. 80 53.3 0 13.3 N.A. 13.3 N.A. 0 0
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 13.3 N.A. 86.6 73.3 26.6 26.6 N.A. 40 N.A. 26.6 20
Percent
Protein Identity: N.A. N.A. N.A. 43.3 40.7 N.A.
Protein Similarity: N.A. N.A. N.A. 59 56.8 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 34 14 0 14 7 7 0 0 0 0 7 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 14 0 7 7 7 0 0 7 7 47 7 0 7 0 % D
% Glu: 0 14 7 7 7 47 7 7 7 7 14 7 20 7 7 % E
% Phe: 0 0 0 7 0 0 14 7 0 7 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 7 0 7 0 7 0 0 7 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 34 0 0 0 0 0 % H
% Ile: 0 0 14 0 0 7 0 0 0 0 0 0 0 0 0 % I
% Lys: 34 54 27 7 20 14 60 7 14 7 14 54 47 0 14 % K
% Leu: 0 7 0 0 0 0 0 0 20 7 0 7 0 0 0 % L
% Met: 0 0 0 0 0 0 0 7 0 0 7 0 0 0 0 % M
% Asn: 7 0 0 0 0 0 0 7 0 7 0 7 0 14 0 % N
% Pro: 0 7 20 0 67 7 0 7 7 7 0 7 7 20 14 % P
% Gln: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 47 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 7 0 7 0 % R
% Ser: 47 0 0 14 0 0 0 40 40 0 0 7 7 34 20 % S
% Thr: 0 0 0 47 0 0 14 7 7 0 14 0 7 7 0 % T
% Val: 0 0 0 0 0 0 0 0 0 7 7 0 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _